PhyloMed: a phylogeny-based test of mediation effect in microbiome.
Genome Biol
; 24(1): 72, 2023 04 11.
Article
em En
| MEDLINE
| ID: mdl-37041566
ABSTRACT
Microbiome data from sequencing experiments contain the relative abundance of a large number of microbial taxa with their evolutionary relationships represented by a phylogenetic tree. The compositional and high-dimensional nature of the microbiome mediator challenges the validity of standard mediation analyses. We propose a phylogeny-based mediation analysis method called PhyloMed to address this challenge. Unlike existing methods that directly identify individual mediating taxa, PhyloMed discovers mediation signals by analyzing subcompositions defined on the phylogenic tree. PhyloMed produces well-calibrated mediation test p-values and yields substantially higher discovery power than existing methods.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microbiota
Idioma:
En
Revista:
Genome Biol
Ano de publicação:
2023
Tipo de documento:
Article