Hyperammonemia induces microglial NLRP3 inflammasome activation via mitochondrial oxidative stress in hepatic encephalopathy.

Cheon, So Yeong; Kim, Min-Yu; Kim, Jeongmin; Kim, Eun Jung; Kam, Eun Hee; Cho, Inja; Koo, Bon-Nyeo; Kim, So Yeon

Cheon, So Yeong; Kim, Min-Yu; Kim, Jeongmin; Kim, Eun Jung; Kam, Eun Hee; Cho, Inja; Koo, Bon-Nyeo; Kim, So Yeon.

Afiliação

Cheon SY; Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju, Republic of Korea.
Kim MY; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim J; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim EJ; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kam EH; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Cho I; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Koo BN; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: koobn@yuhs.ac.
Kim SY; Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: KIMSY326@yuhs.ac.

Biomed J ; 46(5): 100593, 2023 10.

Article em En | MEDLINE | ID: mdl-37059364

Assuntos

Encefalopatia Hepática; Hiperamonemia; Animais; Camundongos; Inflamassomos; Proteína 3 que Contém Domínio de Pirina da Família NLR; Microglia/metabolismo; Encefalopatia Hepática/metabolismo; Lipopolissacarídeos/farmacologia; Lipopolissacarídeos/metabolismo; Hiperamonemia/metabolismo; Amônia/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Estresse Oxidativo

Palavras-chave

Bile duct ligation; Hepatic encephalopathy; Hyperammonemia; Microglia; NLRP3 inflammasome; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatia Hepática / Hiperamonemia Limite: Animals Idioma: En Revista: Biomed J Ano de publicação: 2023 Tipo de documento: Article

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