The ketogenic diet for Dravet syndrome: A multicenter retrospective study.
Nutrition
; 110: 111976, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-37060636
ABSTRACT
OBJECTIVE:
The ketogenic diet (KD) is one of the main treatments for drug-resistant epilepsy. However, there have been few multicenter reports on the use of the KD for the treatment of Dravet syndrome (DS). The aim of this study was to analyze the efficacy and safety of this approach based on a large number of multicenter cases.METHODS:
This was a retrospective, multicenter cohort study from 14 centers in China. All patients were treated with the KD. We compared the effects of KD intervention time, age, and other factors.RESULTS:
From March 2014 to March 2020, we treated 114 patients with DS with the KD. The male-to-female ratio was 6747. The KD median initiation age was 3 y and 4 mo, and the median number of antiseizure medications (ASMs) was 2.4. KD therapy was the first choice for three patients. Exactly 10.5% of the patients started KD therapy after failure of the first ASM therapy, with 35.1% after failure of the second, 44.7% after the third, and 7% after the fourth or more. After KD therapy for 1, 3, 6, and 12 mo, the seizure-free rates were 14%, 32.5%, 30.7%, and 19.3%, respectively; KD efficacy (≥50% reduction in seizure frequency) were 57.9%, 76.3%, 59.6%, and 43%, respectively; the retention rates were 97.4%, 93%, 71.9%, and 46.5%, respectively; and the rates of adverse events were 25.2%, 19.9%, 11%, and 5.7%, respectively.CONCLUSIONS:
Real-world, multicenter data analysis showed that the KD is effective for patients with DS and has a low incidence of side effects.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsias Mioclônicas
/
Dieta Cetogênica
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Epilepsia Resistente a Medicamentos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
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Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Nutrition
Ano de publicação:
2023
Tipo de documento:
Article