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Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease.
Nim, Satra; O'Hara, Darren M; Corbi-Verge, Carles; Perez-Riba, Albert; Fujisawa, Kazuko; Kapadia, Minesh; Chau, Hien; Albanese, Federica; Pawar, Grishma; De Snoo, Mitchell L; Ngana, Sophie G; Kim, Jisun; El-Agnaf, Omar M A; Rennella, Enrico; Kay, Lewis E; Kalia, Suneil K; Kalia, Lorraine V; Kim, Philip M.
Afiliação
  • Nim S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Corbi-Verge C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • Perez-Riba A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • Fujisawa K; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Kapadia M; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Chau H; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Albanese F; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Pawar G; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • De Snoo ML; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Ngana SG; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Kim J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.
  • Rennella E; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Kay LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Kalia SK; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.
  • Kalia LV; Department of Chemistry, University of Toronto, Toronto, ON, Canada.
  • Kim PM; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Nat Commun ; 14(1): 2150, 2023 04 19.
Article em En | MEDLINE | ID: mdl-37076542
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Ano de publicação: 2023 Tipo de documento: Article