A multi-functional nano-system combining PI3K-110&#945;/ß inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency.

Lin, Ruikun; Zhang, Lei; Ye, Biwei; Wang, Yanan; Li, Yi-Dong; Jason, Hsu; Liu, Wenzhen; Hu, Ping; Chen, Jincan; Chen, Zhe-Sheng; Chen, Zhuo

A multi-functional nano-system combining PI3K-110α/ß inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency.

Lin, Ruikun; Zhang, Lei; Ye, Biwei; Wang, Yanan; Li, Yi-Dong; Jason, Hsu; Liu, Wenzhen; Hu, Ping; Chen, Jincan; Chen, Zhe-Sheng; Chen, Zhuo.

Afiliação

Lin R; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China.
Zhang L; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; University of Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China. Electronic address: zhangl@fjirsm.ac.cn.
Ye B; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China.
Wang Y; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China.
Li YD; College of Pharmacy and Health Sciences, St. John's University, Queens, New York, 11439, USA.
Jason H; College of Pharmacy and Health Sciences, St. John's University, Queens, New York, 11439, USA.
Liu W; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
Hu P; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
Chen J; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
Chen ZS; College of Pharmacy and Health Sciences, St. John's University, Queens, New York, 11439, USA.
Chen Z; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China; University of Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China. Electronic address: zchen@fjirsm.ac.cn.

Cancer Lett ; 563: 216181, 2023 06 01.

Article em En | MEDLINE | ID: mdl-37086953

Assuntos

Antineoplásicos; Neoplasias; Animais; Camundongos; Antineoplásicos/farmacologia; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Linhagem Celular Tumoral; Doxorrubicina/farmacologia; Resistência a Múltiplos Medicamentos; Resistencia a Medicamentos Antineoplásicos; Camundongos Nus; Neoplasias/tratamento farmacológico; Fosfatidilinositol 3-Quinases/metabolismo; Humanos

Palavras-chave

Multi-drug resistance (MDR) in cancer; Multifunctional nano-system; P-glycoprotein (P-gp/ABCB1); Phosphatidylinositol-3-kinase (PI3K) 110 subunits; Tumor targeting

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2023 Tipo de documento: Article

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