Comprehensive analysis of the key amino acid substitutions in the polymerase and NP of avian influenza virus that enhance polymerase activity and affect adaptation to mammalian hosts.

Guo, Yanna; Sun, Tongtong; Bai, Xuebing; Liang, Bing; Deng, Lulu; Zheng, Yiqing; Yu, Mengqi; Li, Yinjing; Ping, Jihui

Guo, Yanna; Sun, Tongtong; Bai, Xuebing; Liang, Bing; Deng, Lulu; Zheng, Yiqing; Yu, Mengqi; Li, Yinjing; Ping, Jihui.

Afiliação

Guo Y; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Sun T; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Bai X; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Liang B; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Deng L; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Zheng Y; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Yu M; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Li Y; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Ping J; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety & Jiangsu Engineering Laboratory of Animal Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: jihui.ping@njau.edu.cn.

Vet Microbiol ; 282: 109760, 2023 Jul.

Article em En | MEDLINE | ID: mdl-37120967

Assuntos

Vírus da Influenza A; Influenza Aviária; Animais; Camundongos; Humanos; Substituição de Aminoácidos; Proteínas Virais/genética; Proteínas Virais/metabolismo; RNA Polimerase Dependente de RNA/genética; RNA Polimerase Dependente de RNA/metabolismo; Vírus da Influenza A/genética; Nucleotidiltransferases/genética; Mamíferos; Replicação Viral

Palavras-chave

Influenza A virus; Mammalian adaptation; Pathogenicity; Polymerase activity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Influenza Aviária Limite: Animals / Humans Idioma: En Revista: Vet Microbiol Ano de publicação: 2023 Tipo de documento: Article

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