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Thymus antibody-secreting cells: once forgotten but not lost.
Pioli, KimAnh Trang; Pioli, Peter Dion.
Afiliação
  • Pioli KT; Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Pioli PD; Department of Biochemistry, Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Front Immunol ; 14: 1170438, 2023.
Article em En | MEDLINE | ID: mdl-37122712
ABSTRACT
Antibody-secreting cells are essential contributors to the humoral response. This is due to multiple factors which include 1) the ability to secrete thousands of antibodies per second, 2) the ability to regulate the immune response and 3) the potential to be long-lived. Not surprisingly, these cells can be found in numerous sites within the body which include organs that directly interface with potential pathogens (e.g., gut) and others that provide long-term survival niches (e.g., bone marrow). Even though antibody-secreting cells were first identified in the thymus of both humans and rodents in the 1960s, if not earlier, only recently has this population begun to be extensively investigated. In this article, we provide an update regarding the current breath of knowledge pertaining to thymus antibody-secreting cells and discuss the potential roles of these cells and their impact on health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunidade / Células Produtoras de Anticorpos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunidade / Células Produtoras de Anticorpos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article