Major histocompatibility complex class II in the tumor microenvironment: functions of nonprofessional antigen-presenting cells.
Curr Opin Immunol
; 83: 102330, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37130456
ABSTRACT
Major histocompatibility complex class-II-restricted presentation by nonprofessional antigen-presenting cells in the tumor microenvironment can regulate antitumor T-cell responses. In murine models, tumor cell-specific MHC class II expression decreases in vivo tumor growth, dependent on T cells. Tumor cell-specific MHC class II expression is associated with improved survival and response to immune checkpoint inhibitors in human cancers. Antigen-presenting cancer-associated fibroblasts (apCAF) present MHC class-II-restricted antigens and activate CD4 T cells. The role of MHC class II on apCAFs depends on the cell of origin. MHC class II on tumoral lymphatic endothelial cells leads to expansion of regulatory T cells and increased in vivo tumor growth.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Ano de publicação:
2023
Tipo de documento:
Article