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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi, David M; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M E; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim.
Afiliação
  • Hoi DM; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, 1030 Vienna, Austria; University of Vienna, Center f
  • Junker S; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Junk L; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany. Electronic address: lukas.junk@helmholtz-hips.de.
  • Schwechel K; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Fischel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria.
  • Podlesainski D; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany.
  • Hawkins PME; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia.
  • van Geelen L; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Kaschani F; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany.
  • Leodolter J; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Morreale FE; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Kleine S; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany.
  • Guha S; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany.
  • Rumpel K; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria.
  • Schmiedel VM; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria.
  • Weinstabl H; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria.
  • Meinhart A; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria.
  • Payne RJ; School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia.
  • Kaiser M; University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany.
  • Hartl M; Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria.
  • Boehmelt G; Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria.
  • Kazmaier U; Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany.
  • Kalscheuer R; Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • Clausen T; Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria; Medical University of Vienna, 1030 Vienna, Austria. Electronic address: tim.clausen@imp.ac.at.
Cell ; 186(10): 2176-2192.e22, 2023 05 11.
Article em En | MEDLINE | ID: mdl-37137307
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis / Antituberculosos Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis / Antituberculosos Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article