Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment.

Xu, Pengfei; Yang, Joy C; Chen, Bo; Nip, Christopher; Van Dyke, Jonathan E; Zhang, Xiong; Chen, Hong-Wu; Evans, Christopher P; Murphy, William J; Liu, Chengfei

Xu, Pengfei; Yang, Joy C; Chen, Bo; Nip, Christopher; Van Dyke, Jonathan E; Zhang, Xiong; Chen, Hong-Wu; Evans, Christopher P; Murphy, William J; Liu, Chengfei.

Afiliação

Xu P; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Yang JC; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Chen B; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Nip C; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Van Dyke JE; Flow Cytometry Core, University of California Davis, Sacramento, California, USA.
Zhang X; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Chen HW; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Evans CP; University of California Davis Comprehensive Cancer Center, Sacramento, California, USA.
Murphy WJ; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Liu C; University of California Davis Comprehensive Cancer Center, Sacramento, California, USA.

J Immunother Cancer ; 11(5)2023 05.

Article em En | MEDLINE | ID: mdl-37147019

Assuntos

Neoplasias de Próstata Resistentes à Castração; Receptores Androgênicos; Animais; Humanos; Masculino; Camundongos; Resistencia a Medicamentos Antineoplásicos; Imunossupressores/uso terapêutico; Feniltioidantoína/farmacologia; Feniltioidantoína/uso terapêutico; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Neoplasias de Próstata Resistentes à Castração/patologia; Receptores Androgênicos/genética; Receptores Androgênicos/metabolismo; Microambiente Tumoral

Palavras-chave

Drug Therapy, Combination; Immune Evation; Programmed Cell Death 1 Receptor; Prostatic Neoplasms; Tumor Microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Androgênicos / Neoplasias de Próstata Resistentes à Castração Limite: Animals / Humans / Male Idioma: En Revista: J Immunother Cancer Ano de publicação: 2023 Tipo de documento: Article

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