d-lactate-induced ETosis in cattle polymorphonuclear leucocytes is dependent on the release of mitochondrial reactive oxygen species and the PI3K/Akt/HIF-1 and GSK-3ß pathways.

Quiroga, John; Alarcón, Pablo; Ramírez, María Fernanda; Manosalva, Carolina; Teuber, Stefanie; Carretta, María Daniella; Burgos, Rafael Agustín

Quiroga, John; Alarcón, Pablo; Ramírez, María Fernanda; Manosalva, Carolina; Teuber, Stefanie; Carretta, María Daniella; Burgos, Rafael Agustín.

Afiliação

Quiroga J; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Alarcón P; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Ramírez MF; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Manosalva C; Institute of Pharmacy, Faculty of Sciences, Universidad Austral de Chile, Valdivia, Chile.
Teuber S; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Carretta MD; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
Burgos RA; Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile. Electronic address: rburgos1@uach.cl.

Dev Comp Immunol ; 145: 104728, 2023 08.

Article em En | MEDLINE | ID: mdl-37164278

Assuntos

Proteínas Proto-Oncogênicas c-akt; Transdução de Sinais; Bovinos; Animais; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Glicogênio Sintase Quinase 3 beta/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Ácido Láctico; Fator 1 Induzível por Hipóxia/metabolismo; Hipóxia; Glicogênio

Palavras-chave

(mt)ROS; Bovine PMN; ETosis; HIF-1; Metabolism; d-lactate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteínas Proto-Oncogênicas c-akt Limite: Animals Idioma: En Revista: Dev Comp Immunol Ano de publicação: 2023 Tipo de documento: Article

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