Something new under the sun: caspases promote cell survival under moderate heat stress.
EMBO Rep
; 24(6): e57276, 2023 06 05.
Article
em En
| MEDLINE
| ID: mdl-37165748
ABSTRACT
Since the discovery of caspases in 1993 (Yuan et al, 1993), they have largely been regarded as essential Cys proteases in apoptosis. However, more recently, it has become evident that caspases also have non-apoptotic functions in the so-called caspase-dependent non-lethal processes (CDPs) including cell proliferation and cell differentiation (Aram et al, 2017). While most of the non-apoptotic functions were characterized under normal developmental conditions, a new study by Galasso et al took this examination a step further-to the analysis of moderate stress conditions. The authors now report that caspases have a non-apoptotic prosurvival function in Drosophila ovarian somatic cells exposed to moderate heat stress by controlling Hedgehog signaling and autophagy (Galasso et al, 2023).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caspases
/
Proteínas Hedgehog
Limite:
Animals
Idioma:
En
Revista:
EMBO Rep
Ano de publicação:
2023
Tipo de documento:
Article