Key determinants of success in fecal microbiota transplantation: From microbiome to clinic.
Cell Host Microbe
; 31(5): 712-733, 2023 05 10.
Article
em En
| MEDLINE
| ID: mdl-37167953
ABSTRACT
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the recurrence of Clostridioides difficile infection, but these positive outcomes have only been partially replicated in other diseases. Several factors influence FMT success, including those related to donors and recipients (including diversity and specific composition of the gut microbiome, immune system, and host genetics) as well as to working protocols (fecal amount and number of infusions, route of delivery, and adjuvant treatments). Moreover, initial evidence suggests that the clinical success of FMT may be related to the degree of donor microbial engraftment. The application of cutting-edge technologies for microbiome assessment, along with changes in the current vision of fecal transplants, are expected to improve FMT protocols and outcomes. Here, we review the key determinants of FMT success and insights and strategies that will enable a close integration of lab-based and clinical approaches for increasing FMT success.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
/
Infecções por Clostridium
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Microbiota
/
Microbioma Gastrointestinal
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Cell Host Microbe
Ano de publicação:
2023
Tipo de documento:
Article