Risk of autoimmune skin and connective tissue disorders after mRNA-based COVID-19 vaccination.
J Am Acad Dermatol
; 89(4): 685-693, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37187424
ABSTRACT
BACKGROUND:
Data on the association between the development of autoimmune diseases and COVID-19 vaccination are limited.OBJECTIVE:
To investigate the incidence and risk of autoimmune connective tissue disorders following mRNA-based COVID-19 vaccination.METHODS:
This nationwide population-based study was conducted in South Korea. Individuals who received vaccination between September 8, 2020-December 31, 2021, were identified. Historical prepandemic controls were matched for age and sex in 11 ratio. The incidence rate and risk of disease outcomes were compared.RESULTS:
A total of 3,838,120 vaccinated individuals and 3,834,804 controls without evidence of COVID-19 were included. The risk of alopecia areata, alopecia totalis, primary cicatricial alopecia, psoriasis, vitiligo, anti-neutrophil cytoplasmic antibody-associated vasculitis, sarcoidosis, Behcet disease, Crohn disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, ankylosing spondylitis, dermato/polymyositis, and bullous pemphigoid was not significantly higher in vaccinated individuals than in controls. The risk was comparable according to age, sex, type of mRNA-based vaccine, and cross-vaccination status.LIMITATIONS:
Possible selection bias and residual confounders.CONCLUSION:
These findings suggest that most autoimmune connective tissue disorders are not associated with a significant increase in risk. However, caution is necessary when interpreting results for rare outcomes due to limited statistical power.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Doenças do Tecido Conjuntivo
/
Alopecia em Áreas
/
COVID-19
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2023
Tipo de documento:
Article