An adaptive weighted attention-enhanced deep convolutional neural network for classification of MRI images of Parkinson's disease.

ABSTRACT

BACKGROUND: Parkinson's disease (PD) is the second prevalent neurological diseases with a significant growth rate in incidence. Convolutional neural networks using structural magnetic resonance images (sMRI) are widely used for PD classification. However, the areas of change in the patient's MRI images are small and unfixed. Thus, capturing the features of the areas accurately where the lesions changed became a problem. METHOD: We propose a deep learning framework that combines multi-scale attention guidance and multi-branch feature processing modules to diagnose PD by learning sMRI T2 slice features. In this scheme, firstly, to achieve effective feature transfer and gradient descent, a deep convolutional neural network framework based on dense block is designed. Next, an Adaptive Weighted Attention algorithm is proposed, whose pursers is to extract multi branch and even diverse features. Finally, Dropout layer and SoftMax layer are added to the network structure to obtain good classification results and rich and diverse feature information. The Dropout layer is used to reduce the number of intermediate features to increase the orthogonality between features of each layer. The activation function SoftMax increases the flexibility of the neural network by increasing the degree of fitting to the training set and converting linear to nonlinear. RESULTS: The best performance of the proposed method an accuracy of 92%, a sensitivity of 94%, specificity of 90% and a F1 score of 95% respectively for identifying PD and HC. CONCLUSION: Experiments show that the proposed method can successfully distinguish PD and NC. Good classification results were obtained in PD diagnosis classification task and compared with advanced research methods.