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Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota.
Panyod, Suraphan; Wu, Wei-Kai; Peng, Sin-Yi; Tseng, Yea-Jing; Hsieh, Ya-Chi; Chen, Rou-An; Huang, Huai-Syuan; Chen, Yi-Hsun; Chuang, Hsiao-Li; Hsu, Cheng-Chih; Shen, Ting-Chin David; Yang, Kai-Chien; Ho, Chi-Tang; Wu, Ming-Shiang; Sheen, Lee-Yan.
Afiliação
  • Panyod S; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Wu WK; Center for Food and Biomolecules, National Taiwan University, Taipei, Taiwan, ROC.
  • Peng SY; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, ROC.
  • Tseng YJ; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
  • Hsieh YC; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Chen RA; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Huang HS; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Chen YH; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Chuang HL; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan, ROC.
  • Hsu CC; Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
  • Shen TD; National Laboratory Animal Center, National Applied Research Laboratories, Taipei, Taiwan, ROC.
  • Yang KC; Department of Chemistry, National Taiwan University, Taipei, Taiwan, ROC.
  • Ho CT; Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA.
  • Wu MS; Department and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
  • Sheen LY; Department of Food Science, Rutgers University, New Brunswick, NJ, USA.
NPJ Sci Food ; 7(1): 19, 2023 May 20.
Article em En | MEDLINE | ID: mdl-37210385
Recently, the role of the gut microbiota in diseases, including cardiovascular disease (CVD), has gained considerable research attention. Trimethylamine-N-oxide (TMAO), which is formed during ʟ-carnitine metabolism, promotes the formation of atherosclerotic plaques, causing thrombosis. Here, we elucidated the anti-atherosclerotic effect and mechanism of ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral in Gubra Amylin NASH (GAN) diet with ʟ-carnitine-induced atherosclerosis female ApoE-/- mice. Treatment with GEO at both low and high doses and citral inhibited the formation of aortic atherosclerotic lesions, improved plasma lipid profile, reduced blood sugar, improved insulin resistance, decreased plasma TMAO levels, and inhibited plasma inflammatory cytokines, especially interleukin-1ß. Additionally, GEO and citral treatment modulated gut microbiota diversity and composition by increasing the abundance of beneficial microbes and decreasing the abundance of CVD-related microbes. Overall, these results showed that GEO and citral may serve as potential dietary supplements for CVD prevention by improving gut microbiota dysbiosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Sci Food Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Sci Food Ano de publicação: 2023 Tipo de documento: Article