Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma.

Chen, Quan; Chen, Bingkun; Wang, Chunhua; Hu, Li; Wu, Qiongwen; Zhu, Yanyang; Zhang, Qiuyu

Chen, Quan; Chen, Bingkun; Wang, Chunhua; Hu, Li; Wu, Qiongwen; Zhu, Yanyang; Zhang, Qiuyu.

Afiliação

Chen Q; Institute of Immunotherapy, Fujian Medical University, Fuzhou, China.
Chen B; Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, China.
Wang C; Institute of Immunotherapy, Fujian Medical University, Fuzhou, China.
Hu L; Department of Immunology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Wu Q; Institute of Immunotherapy, Fujian Medical University, Fuzhou, China.
Zhu Y; Institute of Immunotherapy, Fujian Medical University, Fuzhou, China.
Zhang Q; Institute of Immunotherapy, Fujian Medical University, Fuzhou, China.

Front Immunol ; 14: 1159085, 2023.

Article em En | MEDLINE | ID: mdl-37234161

Assuntos

Antígeno B7-H1; Glioma; Humanos; Animais; Camundongos; Antígeno B7-H1/metabolismo; Macrófagos; Linfócitos T/metabolismo; Imunossupressores/farmacologia; Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico/metabolismo; Microambiente Tumoral; Imunoglobulinas/metabolismo; Proteínas de Membrana/metabolismo

Palavras-chave

PD-L1; Siglec-15; combination therapy; glioma; macrophage; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Glioma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2023 Tipo de documento: Article

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