Surgical method for critical sized cranial defects in rat cranium.
MethodsX
; 10: 102208, 2023.
Article
em En
| MEDLINE
| ID: mdl-37234940
ABSTRACT
Cranial tissue models are a widely used model to show the bone repair and the regeneration ability of candidate biomaterials for tissue engineering purposes. Until now, efficacy studies of different biomaterials for calvarial defect bone regeneration have been reported, generally in small animal models. This paper offers a versatile, reliable, and reproducible surgical method for creating a critical-sized cranial defect in rats including critical steps and tried-and-tested tips. The method proposed here,â¢Shows a general procedure for in vivo cranial models.â¢Provide an insight to restore bone tissue repair that may be used in combination with several tissue engineering strategiesâ¢Is a crucial technique that may guide in vivo bone tissue engineering.
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01-internacional
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MEDLINE
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En
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MethodsX
Ano de publicação:
2023
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Article