The Histopathology of Cold Agglutinin Disease-Associated B-Cell Lymphoproliferative Disease.
Am J Clin Pathol
; 160(3): 229-237, 2023 09 01.
Article
em En
| MEDLINE
| ID: mdl-37253147
ABSTRACT
OBJECTIVES:
Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen, a carbohydrate expressed on most cells, including red blood cells. The underlying disease has been characterized in recent years as a distinct B-cell lymphoproliferative disease of the bone marrow, occurring mostly in the elderly. The disease has been now been included as a separate entity in the most recent classifications of mature B-cell neoplasms.METHODS:
A review of the characteristics of cold agglutinin disease is provided, with an emphasis on the pathology features.RESULTS:
A detailed description of the histopathology, immunophenotype, and genetics of cold agglutinin disease is provided and compared to other B-cell lymphoproliferative diseases in the bone marrow with similar features.CONCLUSIONS:
Recognition of the pathology features of cold agglutinin disease allows to distinguish it from other diseases, especially lymphoplasmacytic lymphoma and marginal zone lymphoma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Macroglobulinemia de Waldenstrom
/
Linfoma de Zona Marginal Tipo Células B
/
Anemia Hemolítica Autoimune
/
Transtornos Linfoproliferativos
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Am J Clin Pathol
Ano de publicação:
2023
Tipo de documento:
Article