Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.
Exp Mol Med
; 55(6): 1065-1075, 2023 06.
Article
em En
| MEDLINE
| ID: mdl-37258575
ABSTRACT
The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Actinas
/
Família de Proteínas da Síndrome de Wiskott-Aldrich
Idioma:
En
Revista:
Exp Mol Med
Ano de publicação:
2023
Tipo de documento:
Article