AXL-Induced Autophagy mitigates experimental autoimmune encephalomyelitis by suppressing microglial inflammation via the PI3K/AKT/mTOR signaling pathway.

Sun, Mengjiao; Gong, Panpan; Yuan, Boyao; Liu, Ning; Li, Xiaoling; Zhang, Wenjing; Wang, Manxia

Sun, Mengjiao; Gong, Panpan; Yuan, Boyao; Liu, Ning; Li, Xiaoling; Zhang, Wenjing; Wang, Manxia.

Afiliação

Sun M; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China.
Gong P; Department of Internal Neurology, Gansu Provincial Hospital, No. 204, Donggang West Road, Lanzhou 730000, China.
Yuan B; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China.
Liu N; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China.
Li X; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China.
Zhang W; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China.
Wang M; Department of Neurology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan District, Lanzhou 730030, China. Electronic address: wmx32@aliyun.com.

Mol Immunol ; 159: 15-27, 2023 07.

Article em En | MEDLINE | ID: mdl-37263067

Assuntos

Receptor Tirosina Quinase Axl; Encefalomielite Autoimune Experimental; Animais; Camundongos; Autofagia; Inflamação/patologia; Camundongos Endogâmicos C57BL; Camundongos Knockout; Microglia/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Receptor Tirosina Quinase Axl/metabolismo

Palavras-chave

AXL receptor tyrosine kinase; Autophagy; Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Receptor Tirosina Quinase Axl Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Immunol Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google