Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism.

Phillips, Ian R; Veeravalli, Sunil; Khadayate, Sanjay; Shephard, Elizabeth A

Phillips, Ian R; Veeravalli, Sunil; Khadayate, Sanjay; Shephard, Elizabeth A.

Afiliação

Phillips IR; Department of Structural and Molecular Biology, University College London, London, United Kingdom.
Veeravalli S; School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom.
Khadayate S; Department of Structural and Molecular Biology, University College London, London, United Kingdom.
Shephard EA; MRC London Institute of Medical Sciences (LMS), London, United Kingdom.

PLoS One ; 18(6): e0286692, 2023.

Article em En | MEDLINE | ID: mdl-37267233

Assuntos

Fator 2 Relacionado a NF-E2; Transcriptoma; Animais; Camundongos; Fator 2 Relacionado a NF-E2/metabolismo; Fígado/metabolismo; Estresse Oxidativo; Homeostase; Resposta a Proteínas não Dobradas; Glucose/metabolismo; Carboidratos; Carbono/metabolismo; Lipídeos; Metabolismo dos Lipídeos/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Ano de publicação: 2023 Tipo de documento: Article

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