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Trigeminal nerve stimulation restores hippocampal dopamine deficiency to promote cognitive recovery in traumatic brain injury.
Xu, Jing; Wu, Shaoling; Huo, Lifang; Zhang, Qian; Liu, Lijiaqi; Ye, Zhimin; Cao, Jie; Ma, Haiyun; Shang, Congping; Ma, Chao.
Afiliação
  • Xu J; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China.
  • Wu S; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China.
  • Huo L; Guangzhou Laboratory, Guangzhou 510005, China; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China.
  • Zhang Q; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China.
  • Liu L; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China.
  • Ye Z; Guangzhou Laboratory, Guangzhou 510005, China.
  • Cao J; Guangzhou Laboratory, Guangzhou 510005, China.
  • Ma H; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China.
  • Shang C; Guangzhou Laboratory, Guangzhou 510005, China; Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China; School of Basic Medical Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510005, China. Electronic address: s
  • Ma C; Department of Rehabilitation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China. Electronic address: machao@mail.sysu.edu.cn.
Prog Neurobiol ; 227: 102477, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37270025
Cognitive impairment (CI) is a common neurological disease resulting from traumatic brain injury (TBI). Trigeminal nerve stimulation (TNS) is an emerging, non-invasive, and effective neuromodulation therapy especially for patients suffering from brain function disorders. However, the treatment and recovery mechanisms of TNS remain poorly understood. By using combined advanced technologies, we revealed here that the neuroprotective potential of TNS to improve CI caused by TBI. The study results found that 40 Hz TNS treatment has the ability to improve CI in TBI mice and communicates with central nervous system via the trigeminal ganglion (TG). Transsynaptic virus experiments revealed that TG is connected to the hippocampus (HPC) through the corticotropin-releasing hormone (CRH) neurons of paraventricular hypothalamic nucleus (PVN) and the dopamine transporter (DAT) neurons of substantia nigra pars compacta/ventral tegmental area (SNc/VTA). Mechanistically, the data showed that TNS can increase the release of dopamine in the HPC by activating the following neural circuit: TG→CRH+ PVN→DAT+ SNc/VTA → HPC. Bulk RNA sequencing confirmed changes in the expression of dopamine-related genes in the HPC. This work preliminarily explains the efficacy and mechanism of TNS and adds to the increasing evidence demonstrating that nerve stimulation is an effective method to treat neurological diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Lesões Encefálicas Traumáticas Limite: Animals Idioma: En Revista: Prog Neurobiol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Lesões Encefálicas Traumáticas Limite: Animals Idioma: En Revista: Prog Neurobiol Ano de publicação: 2023 Tipo de documento: Article