Outcomes and Factors Associated with Insufficient Effectiveness of Acute Treatments of Migraine in Japan: Results of the ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) Study.
Drugs Real World Outcomes
; 10(3): 415-428, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37278957
ABSTRACT
BACKGROUND:
Knowledge of patient outcomes and treatment effectiveness associated with acute migraine treatments in Japan is lacking.OBJECTIVE:
To describe patient-reported outcomes (PROs) and treatment effectiveness in three acute treatment groups from OVERCOME (Japan) over-the-counter (OTC) only, prescription nonsteroidal anti-inflammatory drugs/acetaminophen (Rx-NSAIDs/ACE) only, and triptans.METHODS:
OVERCOME (Japan) was an observational, cross-sectional, population-based web survey of people with migraine (July-September 2020). PROs, including the Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Interictal Burden Scale (MIBS-4), Migraine Disability Assessment (MIDAS), and Work Productivity and Activity Impairment Questionnaire Migraine (WPAI-M), were compared pairwise between treatment groups. Logistic regression was used to examine treatment effectiveness.RESULTS:
The analysis included 9075 survey respondents (OTC only n = 5791; Rx-NSAIDs/ACE only n = 751; triptans n = 2533). Triptan users reported the lowest MSQ scores, most severe disability (MIDAS 20.7% versus 6.3% and 11.6%) and severe interictal burden (MIBS-4 50.1% versus 21.2% and 19.8%), and greatest work impairment (WPAI-M 50.4% versus 32.2% and 30.8%) compared with the OTC and Rx-NSAIDs/ACE groups, respectively. Treatment effectiveness was very poor-to-poor for 60.9%, 43.1%, and 47.6% of the triptan, OTC, and Rx-NSAIDs/ACE groups, respectively. Severe interictal burden was significantly associated with insufficient treatment effectiveness (odds ratios, severe versus no burden 0.47 [95% confidence interval 0.40-0.54], 0.56 [0.35-0.89], and 0.41 [0.32-0.52], for the OTC, Rx-NSAIDs/ACE, and triptan groups, respectively).CONCLUSION:
People with high migraine burden used triptans for acute treatment, but many reported poor treatment effectiveness. Education may be required to promote better treatments, including earlier introduction of migraine-specific acute and preventive medications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
/
Screening_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
Drugs Real World Outcomes
Ano de publicação:
2023
Tipo de documento:
Article