Platelet glycogenolysis is important for energy production and function.
Platelets
; 34(1): 2222184, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37292023
What did we know? Activated platelets transition from a low-energy-requiring, resting state to a high-energy-demanding state.Platelet glycogen is degraded upon activation.Glycogen storage disorders and glycogen phosphorylase inhibitors are associated with bleeding.What did we discover? Glycogen turnover occurs in resting platelets and its degradation is important for platelet functions.Glycogen phosphorylase inhibitors block secretion and clot contraction of which the latter can be reversed with alternative metabolic fuels.Glucose derived from glycogen may be routed through TCA/OxPhos versus aerobic glycolysis.What is the impact? Glycogen breakdown contributes to the high energy requirements of platelet function.Our work offers insights into potential energy sources in activated platelets.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Doença de Depósito de Glicogênio
/
Glicogenólise
Limite:
Humans
Idioma:
En
Revista:
Platelets
Ano de publicação:
2023
Tipo de documento:
Article