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Extrafollicular IgD-CD27-CXCR5-CD11c- DN3 B cells infiltrate inflamed tissues in autoimmune fibrosis and in severe COVID-19.
Allard-Chamard, Hugues; Kaneko, Naoki; Bertocchi, Alice; Sun, Na; Boucau, Julie; Kuo, Hsiao-Hsuan; Farmer, Jocelyn R; Perugino, Cory; Mahajan, Vinay S; Murphy, Samuel J H; Premo, Katherine; Diefenbach, Thomas; Ghebremichael, Musie; Yuen, Grace; Kotta, Alekhya; Akman, Zafer; Lichterfeld, Mathias; Walker, Bruce D; Yu, Xu G; Moriyama, Masafumi; Maehara, Takashi; Nakamura, Seiji; Stone, John H; Padera, Robert F; Pillai, Shiv.
Afiliação
  • Allard-Chamard H; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Rheumatology, Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke et Centre de Recherche Clinique Étienne-Le Bel, Sherbrooke, QC J1K 2R1, Canada.
  • Kaneko N; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
  • Bertocchi A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Sun N; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Boucau J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Kuo HH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Farmer JR; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Perugino C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Rheumatology Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Mahajan VS; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Murphy SJH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Premo K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Diefenbach T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Ghebremichael M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Yuen G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Kotta A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Akman Z; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Biology and Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Moriyama M; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
  • Maehara T; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
  • Nakamura S; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
  • Stone JH; Division of Rheumatology Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Padera RF; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Pillai S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: pillai@helix.mgh.harvard.edu.
Cell Rep ; 42(6): 112630, 2023 06 27.
Article em En | MEDLINE | ID: mdl-37300833
ABSTRACT
Although therapeutic B cell depletion dramatically resolves inflammation in many diseases in which antibodies appear not to play a central role, distinct extrafollicular pathogenic B cell subsets that accumulate in disease lesions have hitherto not been identified. The circulating immunoglobulin D (IgD)-CD27-CXCR5-CD11c+ DN2 B cell subset has been previously studied in some autoimmune diseases. A distinct IgD-CD27-CXCR5-CD11c- DN3 B cell subset accumulates in the blood both in IgG4-related disease, an autoimmune disease in which inflammation and fibrosis can be reversed by B cell depletion, and in severe COVID-19. These DN3 B cells prominently accumulate in the end organs of IgG4-related disease and in lung lesions in COVID-19, and double-negative B cells prominently cluster with CD4+ T cells in these lesions. Extrafollicular DN3 B cells may participate in tissue inflammation and fibrosis in autoimmune fibrotic diseases, as well as in COVID-19.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Doença Relacionada a Imunoglobulina G4 / COVID-19 Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Subpopulações de Linfócitos B / Doença Relacionada a Imunoglobulina G4 / COVID-19 Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article