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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
Povero, Davide; Lazic, Milos; McBride, Christopher; Ambrus-Aikelin, Geza; Stansfield, Ryan; Johnson, Casey D; Santini, Angelina M; Pranadinata, Rama F; McGeough, Matthew D; Stafford, Jeffrey A; Hoffman, Hal M; Feldstein, Ariel E; Veal, James M; Bain, Gretchen.
Afiliação
  • Povero D; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.) povero.davide@mayo.edu.
  • Lazic M; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • McBride C; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Ambrus-Aikelin G; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Stansfield R; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Johnson CD; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Santini AM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Pranadinata RF; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • McGeough MD; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Stafford JA; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Hoffman HM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Feldstein AE; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Veal JM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
  • Bain G; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).
J Pharmacol Exp Ther ; 386(2): 242-258, 2023 08.
Article em En | MEDLINE | ID: mdl-37308266
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2023 Tipo de documento: Article