Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain <i>via</i> regulation of PTEN/PI3K/IL-6 signalling.

Leung, Siu Yi Doreen; Meng, Fei; Liu, Jingjing; Liu, Aijia Jessica; Ng, Hei Lui Lhotse; Cheung, Chi Wai; Sau Ching Wong, Stanley

Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling.

Leung, Siu Yi Doreen; Meng, Fei; Liu, Jingjing; Liu, Aijia Jessica; Ng, Hei Lui Lhotse; Cheung, Chi Wai; Sau Ching Wong, Stanley.

Afiliação

Leung SYD; Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Meng F; Department of Anaesthesiology, Laboratory and Clinical Research Institute for Pain, University of Hong Kong, Hong Kong, China.
Liu J; Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Liu AJ; Department of Anaesthesiology, Laboratory and Clinical Research Institute for Pain, University of Hong Kong, Hong Kong, China.
Ng HLL; Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Cheung CW; Department of Anaesthesiology, Laboratory and Clinical Research Institute for Pain, University of Hong Kong, Hong Kong, China.
Sau Ching Wong S; Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Mol Pain ; 19: 17448069231185232, 2023.

Article em En | MEDLINE | ID: mdl-37314769

Assuntos

Dor Crônica; Síndromes da Dor Regional Complexa; Propofol; Distrofia Simpática Reflexa; Camundongos; Animais; Hiperalgesia/complicações; Hiperalgesia/tratamento farmacológico; Hiperalgesia/metabolismo; Propofol/farmacologia; Propofol/uso terapêutico; Interleucina-6; Fosfatidilinositol 3-Quinases; Proteínas Proto-Oncogênicas c-akt; Distrofia Simpática Reflexa/metabolismo; Isquemia; Anestésicos Intravenosos; Corno Dorsal da Medula Espinal/metabolismo; Analgésicos/uso terapêutico; Modelos Animais de Doenças

Palavras-chave

IL-6; PI3K; PTEN; Propofol; chronic post-ischaemic pain; chronic regional pain syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofia Simpática Reflexa / Propofol / Síndromes da Dor Regional Complexa / Dor Crônica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Pain Ano de publicação: 2023 Tipo de documento: Article

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