RNA aptamers with specific binding affinity to CD40 (CD40Apt) represents a promising antagonist of the CD40-CD40L signaling for thyroid-associated ophthalmopathy (TAO) treatment in mouse.

Chen, Yizhi; Tang, Renhong; Xiong, Wei; Zhang, Feng; Wang, Nuo; Xie, Bingyu; Cao, Jiamin; Chen, Zhuokun; Ma, Chen

Chen, Yizhi; Tang, Renhong; Xiong, Wei; Zhang, Feng; Wang, Nuo; Xie, Bingyu; Cao, Jiamin; Chen, Zhuokun; Ma, Chen.

Afiliação

Chen Y; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Tang R; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Xiong W; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China. weixiong420@csu.edu.cn.
Zhang F; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China. fengz2022@csu.edu.cn.
Wang N; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Xie B; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Cao J; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Chen Z; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.
Ma C; Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha, China.

J Transl Med ; 21(1): 396, 2023 06 18.

Article em En | MEDLINE | ID: mdl-37331977

Assuntos

Aptâmeros de Nucleotídeos; Oftalmopatia de Graves; Animais; Camundongos; Oftalmopatia de Graves/tratamento farmacológico; Oftalmopatia de Graves/genética; Oftalmopatia de Graves/metabolismo; Ligante de CD40/metabolismo; NF-kappa B/metabolismo; Antígenos CD40/metabolismo; Órbita/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Colágeno/metabolismo; Fibroblastos/metabolismo

Palavras-chave

CD40 aptamer (CD40Apt); Orbital fibroblast activation; The CD40-CD40L signaling; Thyroid-associated ophthalmopathy (TAO)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oftalmopatia de Graves / Aptâmeros de Nucleotídeos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: J Transl Med Ano de publicação: 2023 Tipo de documento: Article

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