Unusual selectivity in the ring-opening of γ-valerolactone oxide by amines.
Chem Commun (Camb)
; 59(54): 8444-8447, 2023 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-37337749
ABSTRACT
Primary and secondary amines selectively react with the lactone moiety of γ-valerolactone oxide (GVLO). Several primary amines afforded the resulting epoxyamides with an intact epoxy group. In some cases addition of two equivalents of amine resulted in additional epoxide opening to give α,γ-dihydroxy-ß-amino-amides. The selective lactone-opening in GVLO was further corroborated by DFT-studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2023
Tipo de documento:
Article