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Dietary alpha-ketoglutarate enhances intestinal immunity by Th17/Treg immune response in piglets after lipopolysaccharide challenge.
Liu, Guang M; Lu, Jia J; Sun, Wei X; Jia, Gang; Zhao, Hua; Chen, Xiao L; Tian, Gang; Cai, Jing Y; Zhang, Rui N; Wang, Jing.
Afiliação
  • Liu GM; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
  • Lu JJ; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan 611130, China.
  • Sun WX; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
  • Jia G; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan 611130, China.
  • Zhao H; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
  • Chen XL; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan 611130, China.
  • Tian G; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
  • Cai JY; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan 611130, China.
  • Zhang RN; Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
  • Wang J; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Chengdu, Sichuan 611130, China.
J Anim Sci ; 1012023 Jan 03.
Article em En | MEDLINE | ID: mdl-37348134
Immature digestive and immune systems cause a variety of problems. The balance of helper Tcells 17 (Th17) and regulatory T cells (Treg) is critical in maintaining normal immune function in animals. Piglets' growth performance and immune function are all influenced by alpha-ketoglutarate (AKG). However, how AKG exerts its effect on intestinal immunity in piglets through modulating the immune signaling of Th17/Treg biology has not been explored. In this study, an inflammation model was established by lipopolysaccharide (LPS) injection. This study was to test the hypothesis that AKG can enhance growth performance and attenuate LPS-challenged intestinal inflammation by modulating Th17/Treg response. We concluded that dietary AKG can improve the growth performance of piglets. Dietary AKG alleviated intestinal inflammation induced by LPS through the Th17/Treg response, thereby improving intestinal immunity. These findings can provide a theoretical foundation for utilizing AKG in weaned piglet diets for the regulation of intestinal immune activity through nutrition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Ácidos Cetoglutáricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Anim Sci Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Ácidos Cetoglutáricos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Anim Sci Ano de publicação: 2023 Tipo de documento: Article