Focus on Metformin: Its Role and Safety in Pregnancy and Beyond.
Drugs
; 83(11): 985-999, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-37354354
ABSTRACT
Metformin is used worldwide in the treatment of type 2 diabetes and has been used in the treatment of diabetes in pregnancy since the 1970s. It is highly acceptable to patients due to its ease of administration, cost and adverse effect profile. It is effective in reducing macrosomia, large-for-gestational-age infants and reduces maternal weight gain. Despite its many advantages, metformin has been associated with reductions in foetal size and has been associated with an increase in infants born small-for-gestational-age in certain cohorts. In this article, we review its efficacy, adverse effects and long-term follow-up before, during and after pregnancy for both mother and infant. We also evaluate the other forms of treatment for gestational diabetes, including oral therapies, insulin therapy and emerging treatments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Gestacional
/
Diabetes Mellitus Tipo 2
/
Metformina
Limite:
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Drugs
Ano de publicação:
2023
Tipo de documento:
Article