Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone.

Park, Yu Mi; Meyer, Markus R; Müller, Rolf; Herrmann, Jennifer

Park, Yu Mi; Meyer, Markus R; Müller, Rolf; Herrmann, Jennifer.

Afiliação

Park YM; Helmholtz Centre for Infection Research, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8 1, Saarland University, 66123 Saarbrücken, Germany.
Meyer MR; Environmental Safety Group, Korea Institute of Science and Technology (KIST) Europe, 66123 Saarbrücken, Germany.
Müller R; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Herrmann J; Center for Molecular Signaling (PZMS), Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Experimental and Clinical Toxicology, Saarland University, 66421 Homburg, Germany.

Int J Mol Sci ; 24(12)2023 Jun 13.

Article em En | MEDLINE | ID: mdl-37373226

Assuntos

Antagonistas de Entorpecentes; Peixe-Zebra; Animais; Humanos; Antagonistas de Entorpecentes/farmacologia; Naloxona/farmacologia; Larva; Projetos Piloto; Espectrometria de Massas

Palavras-chave

drug metabolism and pharmacokinetics (DMPK); mass spectrometry imaging (MSI); naloxone; opioid antagonist; spatial drug distribution; zebrafish larvae model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Antagonistas de Entorpecentes Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article

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