Self-Assembly of Cysteine into Nanofibrils Precedes Cystine Crystal Formation: Implications for Aggregation Inhibition.

Oluwatoba, Damilola S; Chakraborty, Poulami; Bar-Yosef, Dana Laor; Limbach, Miranda N; Gazit, Ehud; Do, Thanh D

Oluwatoba, Damilola S; Chakraborty, Poulami; Bar-Yosef, Dana Laor; Limbach, Miranda N; Gazit, Ehud; Do, Thanh D.

Afiliação

Oluwatoba DS; Department of Chemistry, University of Tennessee, Knoxville, Knoxville, Tennessee 37996, United States.
Chakraborty P; Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 6997801, Israel.
Bar-Yosef DL; Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 6997801, Israel.
Limbach MN; Department of Chemistry, University of Tennessee, Knoxville, Knoxville, Tennessee 37996, United States.
Gazit E; Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel Aviv 6997801, Israel.
Do TD; Department of Chemistry, University of Tennessee, Knoxville, Knoxville, Tennessee 37996, United States.

ACS Appl Mater Interfaces ; 15(27): 32177-32187, 2023 Jul 12.

Article em En | MEDLINE | ID: mdl-37387421

Assuntos

Cisteína; Cistinúria; Humanos; Cisteína/química; Cistina/química; Cistinúria/tratamento farmacológico; Aminoácidos/uso terapêutico; Amiloide/química; Dissulfetos/uso terapêutico

Palavras-chave

amyloid fibrils; cystinuria; hexagonal crystals; mass spectrometry; nuclear magnetic resonance; transmission electron spectroscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cisteína / Cistinúria Limite: Humans Idioma: En Revista: ACS Appl Mater Interfaces Ano de publicação: 2023 Tipo de documento: Article

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