High throughput screening identifies auranofin and pentamidine as potent compounds that lower IFN-Î³-induced Nitric Oxide and inflammatory responses in mice: DSS-induced colitis and Salmonella Typhimurium-induced sepsis.

Chattopadhyay, Avik; Joseph, Joel P; Jagdish, Sirisha; Chaudhuri, Somak; Ramteke, Nikita S; Karhale, Aagosh Kishore; Waturuocha, Uchenna; Saini, Deepak Kumar; Nandi, Dipankar

Chattopadhyay, Avik; Joseph, Joel P; Jagdish, Sirisha; Chaudhuri, Somak; Ramteke, Nikita S; Karhale, Aagosh Kishore; Waturuocha, Uchenna; Saini, Deepak Kumar; Nandi, Dipankar.

Afiliação

Chattopadhyay A; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Joseph JP; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore 560012, India.
Jagdish S; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Chaudhuri S; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Ramteke NS; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Karhale AK; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.
Waturuocha U; Department of Developmental Biology and Genetics, Indian Institute of Science, Bangalore 560012, India.
Saini DK; Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore 560012, India; Department of Developmental Biology and Genetics, Indian Institute of Science, Bangalore 560012, India.
Nandi D; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. Electronic address: nandi@iisc.ac.in.

Int Immunopharmacol ; 122: 110569, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37392571

Assuntos

Colite; Sepse; Camundongos; Animais; Interferon gama/metabolismo; Óxido Nítrico/metabolismo; Salmonella typhimurium/fisiologia; Auranofina/farmacologia; Auranofina/uso terapêutico; Pentamidina; Ensaios de Triagem em Larga Escala; Óxido Nítrico Sintase Tipo II/genética; Óxido Nítrico Sintase Tipo II/metabolismo; Colite/induzido quimicamente; Colite/tratamento farmacológico

Palavras-chave

Colitis; Interferon-gamma; LOPAC®(1280); Nitric Oxide; Peritonitis; Sepsis

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Colite / Sepse Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2023 Tipo de documento: Article

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