NF-&#954;B pathway affects silica nanoparticle-induced fibrosis via inhibited inflammatory response and epithelial-mesenchymal transition in 3D co-culture.

Yang, Xiaojing; Zhang, Jing; Xiong, Min; Yang, Yushan; Yang, Pan; Li, Ning; Shi, Fan; Zhu, Yaxin; Guo, Keyun; Jin, Yulan

NF-κB pathway affects silica nanoparticle-induced fibrosis via inhibited inflammatory response and epithelial-mesenchymal transition in 3D co-culture.

Yang, Xiaojing; Zhang, Jing; Xiong, Min; Yang, Yushan; Yang, Pan; Li, Ning; Shi, Fan; Zhu, Yaxin; Guo, Keyun; Jin, Yulan.

Afiliação

Yang X; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Zhang J; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Xiong M; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Yang Y; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Yang P; Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei, China.
Li N; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Shi F; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Zhu Y; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Guo K; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Jin Y; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China. Electronic address: 13932579151@163.com.

Toxicol Lett ; 383: 141-151, 2023 Jul 01.

Article em En | MEDLINE | ID: mdl-37394155

Assuntos

Transição Epitelial-Mesenquimal; Fibrose; Pneumopatias; Nanopartículas; Dióxido de Silício; Animais; Humanos; Camundongos; Carcinoma Pulmonar de Células não Pequenas; Técnicas de Cocultura; Transição Epitelial-Mesenquimal/imunologia; Fibrose/etiologia; Fibrose/imunologia; Interleucina-6; Neoplasias Pulmonares; Nanopartículas/toxicidade; NF-kappa B/metabolismo; Dióxido de Silício/toxicidade; Fator de Necrose Tumoral alfa/metabolismo; Pneumopatias/etiologia; Pneumopatias/imunologia

Palavras-chave

3D co-culture; Matrigel; NF-κB; Pulmonary fibrosis; SiNPs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Dióxido de Silício / Nanopartículas / Transição Epitelial-Mesenquimal / Pneumopatias Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Toxicol Lett Ano de publicação: 2023 Tipo de documento: Article

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