Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response.
J Rheumatol
; 50(9): 1103-1113, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37399470
ABSTRACT
Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage. We will review the role and potential drivers of IFN-I dysregulation in 5 prototypic autoimmune diseases systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, primary Sjögren syndrome, and systemic sclerosis. We will also discuss current therapeutic strategies that directly or indirectly target the IFN-I system.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Interferon Tipo I
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Lúpus Eritematoso Sistêmico
Limite:
Humans
Idioma:
En
Revista:
J Rheumatol
Ano de publicação:
2023
Tipo de documento:
Article