PRMT5 knockdown enhances cell viability and suppresses cell apoptosis, oxidative stress, inflammation and endothelial dysfunction in ox-LDL-induced vascular endothelial cells via interacting with PDCD4.

Fei, Xiaohong; Cen, Xuejiang; Zhao, Ruochi; Wang, Jian; Cui, Hanbin

Fei, Xiaohong; Cen, Xuejiang; Zhao, Ruochi; Wang, Jian; Cui, Hanbin.

Afiliação

Fei X; Cardiology Center, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China. Electronic address: Feixiaohong_1@163.com.
Cen X; Cardiology Center, Zhejiang Provincial People's Hospital, Hangzhou, 310014, Zhejiang, PR China.
Zhao R; Cardiology Center, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China.
Wang J; Cardiology Center, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China.
Cui H; Cardiology Center, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo First Hospital, Ningbo, 315010, Zhejiang, PR China.

Int Immunopharmacol ; 122: 110529, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37399609

Assuntos

MicroRNAs; Estresse Oxidativo; Humanos; Células Endoteliais da Veia Umbilical Humana; Sobrevivência Celular/genética; Lipoproteínas LDL/farmacologia; Lipoproteínas LDL/metabolismo; Apoptose/genética; Inflamação/genética; Inflamação/metabolismo; MicroRNAs/metabolismo; Proteína-Arginina N-Metiltransferases/genética; Proteína-Arginina N-Metiltransferases/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Proteínas Reguladoras de Apoptose/genética; Proteínas Reguladoras de Apoptose/metabolismo

Palavras-chave

Endothelial dysfunction; Oxidative damage; PDCD4; PRMT5; Vascular endothelial cells; ox-LDL

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / MicroRNAs Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int Immunopharmacol Ano de publicação: 2023 Tipo de documento: Article

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