Drug extravasation with Enfortumab vedotin.
J Oncol Pharm Pract
; 29(7): 1789-1792, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37401244
ABSTRACT
INTRODUCTION:
Enfortumab vedotin is an antibody drug conjugate approved for management of pretreated locally advanced or metastatic urothelial carcinoma, which is associated with a rare risk of drug extravasation and soft tissue reactions. CASE REPORT We report two cases of EV extravasation with subsequent development of bullae and cellulitis. MANAGEMENT ANDOUTCOME:
They were both treated for cellulitis and had conservative management without surgical intervention and were able to resume treatment with Enfortumab vedotin without subsequent adverse events.DISCUSSION:
We propose that EV acts as a vesicant upon extravasation, highlight measures to prevent extravasation events, and encourage appropriate measures when dealing such as attempt of aspiration, removal of catheter, application of compresses, and thorough documentation with photographic evidence.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carcinoma de Células de Transição
Limite:
Humans
Idioma:
En
Revista:
J Oncol Pharm Pract
Ano de publicação:
2023
Tipo de documento:
Article