The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol-based compound tuning glutathione and thioredoxin systems.

Bruschi, Michela; Biancucci, Federica; Masini, Sofia; Piacente, Francesco; Ligi, Daniela; Bartoccini, Francesca; Antonelli, Antonella; Mannello, Ferdinando; Bruzzone, Santina; Menotta, Michele; Fraternale, Alessandra; Magnani, Mauro

Bruschi, Michela; Biancucci, Federica; Masini, Sofia; Piacente, Francesco; Ligi, Daniela; Bartoccini, Francesca; Antonelli, Antonella; Mannello, Ferdinando; Bruzzone, Santina; Menotta, Michele; Fraternale, Alessandra; Magnani, Mauro.

Afiliação

Bruschi M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Biancucci F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Masini S; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Piacente F; Department of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, Genoa, GE, Italy.
Ligi D; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Bartoccini F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Antonelli A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Mannello F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Bruzzone S; Department of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genoa, Genoa, GE, Italy.
Menotta M; IRCCS, Ospedale Policlinico San Martino, Genoa, GE, Italy.
Fraternale A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.
Magnani M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy.

Biofactors ; 49(6): 1205-1222, 2023.

Article em En | MEDLINE | ID: mdl-37409789

Assuntos

Células Endoteliais; NAD; Humanos; Espécies Reativas de Oxigênio/metabolismo; Células Endoteliais/metabolismo; NAD/metabolismo; Proteômica; Oxirredução; Hipóxia; Tiorredoxinas/genética; Tiorredoxinas/metabolismo; Glutationa/metabolismo; Oxigênio/metabolismo; Compostos de Enxofre; Compostos de Sulfidrila

Palavras-chave

I-152; ROS; antioxidant; endothelial cells; glutathione; hypoxia; redox; thioredoxin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Endoteliais / NAD Limite: Humans Idioma: En Revista: Biofactors Ano de publicação: 2023 Tipo de documento: Article

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