Mendelian randomization study of diabetes and dementia in the Million Veteran Program.
Alzheimers Dement
; 19(10): 4367-4376, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37417779
ABSTRACT
INTRODUCTION:
Diabetes and dementia are diseases of high health-care burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective was to evaluate evidence of causality between these two common diseases.METHODS:
We conducted a one-sample Mendelian randomization (MR) analysis in the US Department of Veterans Affairs Million Veteran program. The study included 334,672 participants ≥65 years of age with type 2 diabetes and dementia case-control status and genotype data.RESULTS:
For each standard deviation increase in genetically predicted diabetes, we found increased odds of three dementia diagnoses in non-Hispanic White participants (all-cause odds ratio [OR] = 1.07 [1.05-1.08], P = 3.40E-18; vascular OR = 1.11 [1.07-1.15], P = 3.63E-09, Alzheimer's disease [AD] OR = 1.06 [1.02-1.09], P = 6.84E-04) and non-Hispanic Black participants (all-cause OR = 1.06 [1.02-1.10], P = 3.66E-03, vascular OR = 1.11 [1.04-1.19], P = 2.20E-03, AD OR = 1.12 [1.02-1.23], P = 1.60E-02) but not in Hispanic participants (all P > 0.05).DISCUSSION:
We found evidence of causality between diabetes and dementia using a one-sample MR study, with access to individual level data, overcoming limitations of prior studies using two-sample MR techniques.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Veteranos
/
Diabetes Mellitus Tipo 2
/
Doença de Alzheimer
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2023
Tipo de documento:
Article