Comparative Toxicity of Seven Aqueous Film-Forming Foam to In Vitro Systems and Mus.
Environ Toxicol Chem
; 42(11): 2364-2374, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37431895
ABSTRACT
The comparative toxicity of six per- and polyfluoroalkyl substance (PFAS)-free and one PFAS-containing aqueous film-forming foam (AFFF) was evaluated in an outbred mouse species as well as several in vitro assays. The in vivo toxicological profile of PFAS-free AFFFs in short-term, high-concentration exposures is different than that of a PFAS-containing AFFF. The PFAS-containing reference product induced increased liver weights, while the PFAS-free AFFFs were linked to either decreased or unaffected relative liver weights. The in vitro toxicological profile across PFAS-free AFFFs was uniform except in the Microtox® assay, where thresholds were variable and spanned several orders of magnitude. This direct comparison of products through short-term toxicity tests and in vitro screenings represents early data to support evaluation of potential regrettable substitutions when selecting alternative PFAS-free AFFFs. Further work in diverse taxa (e.g., aquatic organisms, terrestrial invertebrates, birds) and mammalian studies capturing sensitive life stages will refine and expand this data set across a range of risk-relevant toxicological endpoints. Environ Toxicol Chem 2023;422364-2374. Published 2023. This article is a U.S. Government work and is in the public domain in the USA.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poluentes Químicos da Água
/
Fluorocarbonos
Limite:
Animals
Idioma:
En
Revista:
Environ Toxicol Chem
Ano de publicação:
2023
Tipo de documento:
Article