The Origin, Differentiation, and Functions of Cancer-Associated Fibroblasts in Gastrointestinal Cancer.
Cell Mol Gastroenterol Hepatol
; 16(4): 503-511, 2023.
Article
em En
| MEDLINE
| ID: mdl-37451403
ABSTRACT
Emerging evidence has shown the importance of the tumor microenvironment in tumorigenesis and progression. Cancer-associated fibroblasts (CAFs) are one of the most infiltrated stroma cells of the tumor microenvironment in gastrointestinal tumors. CAFs play crucial roles in tumor development and therapeutic response by biologically secreting soluble factors or structurally remodeling the extracellular matrix. Conceivably, CAFs may become excellent targets for tumor prevention and treatment. However, the limited knowledge of the heterogeneity of CAFs represents a huge challenge for clinically targeting CAFs. In this review, we summarize the newest understanding of gastrointestinal CAFs, with a special focus on their origin, differentiation, and function. We also discuss the current understanding of CAF subpopulations as shown by single-cell technologies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibroblastos Associados a Câncer
/
Neoplasias Gastrointestinais
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Cell Mol Gastroenterol Hepatol
Ano de publicação:
2023
Tipo de documento:
Article