Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease.
Drug Discov Today
; 28(9): 103718, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37467881
ABSTRACT
Vision loss causes a significant burden on individuals and communities on a financial, emotional and social level. Common causes include age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and retinitis pigmentosa (RP; also known as 'rod-cone dystrophy'). As the population continues to grow and age globally, an increasing number of people will experience vision loss. Hence, there is an urgent need to develop therapies that can curb early pathological events. The broccoli-derived compound, sulforaphane (SFN), is reported to have multiple health benefits and modes of action. In this review, we outline the preclinical findings on SFN in ocular diseases and discuss the future clinical testing of this compound.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Brassica
/
Retinose Pigmentar
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Degeneração Macular
Limite:
Humans
Idioma:
En
Revista:
Drug Discov Today
Ano de publicação:
2023
Tipo de documento:
Article