A biomimetic approach for the concise total synthesis of greenwaylactams A-C.
Org Biomol Chem
; 21(31): 6317-6319, 2023 Aug 09.
Article
em En
| MEDLINE
| ID: mdl-37496493
ABSTRACT
A concise, racemic total synthesis of three sesquiterpenoid alkaloids (greenwaylactams A-C) exhibiting an unprecedented 8-membered benzolactam is disclosed. Key transformations of this work include the ring expansion through cleavage of an indole via Witkop oxidation, as well as an HFIP mediated cationic cyclisation to build up the pentacyclic carbon skeleton.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Ano de publicação:
2023
Tipo de documento:
Article