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Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.
Viox, Elise G; Hoang, Timothy N; Upadhyay, Amit A; Nchioua, Rayhane; Hirschenberger, Maximilian; Strongin, Zachary; Tharp, Gregory K; Pino, Maria; Nguyen, Kevin; Harper, Justin L; Gagne, Matthew; Marciano, Shir; Boddapati, Arun K; Pellegrini, Kathryn L; Pradhan, Arpan; Tisoncik-Go, Jennifer; Whitmore, Leanne S; Karunakaran, Kirti A; Roy, Melissa; Kirejczyk, Shannon; Curran, Elizabeth H; Wallace, Chelsea; Wood, Jennifer S; Connor-Stroud, Fawn; Voigt, Emily A; Monaco, Christopher M; Gordon, David E; Kasturi, Sudhir P; Levit, Rebecca D; Gale, Michael; Vanderford, Thomas H; Silvestri, Guido; Busman-Sahay, Kathleen; Estes, Jacob D; Vaccari, Monica; Douek, Daniel C; Sparrer, Konstantin M J; Johnson, R Paul; Kirchhoff, Frank; Schreiber, Gideon; Bosinger, Steven E; Paiardini, Mirko.
Afiliação
  • Viox EG; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Hoang TN; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Upadhyay AA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Strongin Z; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Tharp GK; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Pino M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Nguyen K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Harper JL; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Gagne M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Marciano S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Boddapati AK; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Pellegrini KL; Emory NPRC Genomics Core Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Pradhan A; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Tisoncik-Go J; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Whitmore LS; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Karunakaran KA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Roy M; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Kirejczyk S; StageBio, 5930 Main St., Mount Jackson, VA 22842, USA.
  • Curran EH; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Wallace C; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Connor-Stroud F; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Voigt EA; RNA Vaccines Group, Access to Advanced Health Institute, Seattle, WA 98102, USA.
  • Monaco CM; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Gordon DE; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Kasturi SP; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Levit RD; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Gale M; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Vanderford TH; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Silvestri G; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Busman-Sahay K; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Estes JD; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Vaccari M; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Douek DC; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Sparrer KMJ; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Johnson RP; Department of Clinical Medicine, Aarhus University, Aarhus 8000, Denmark.
  • Kirchhoff F; School of Health and Biomedical Sciences, College of Science, Engineering and Health, RMIT University, Melbourne, VIC 3000, Australia.
  • Schreiber G; Division of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA.
  • Bosinger SE; Department of Microbiology and Immunology, Tulane School of Medicine, New Orleans, LA 70112, USA.
  • Paiardini M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sci Immunol ; 8(85): eadg0033, 2023 07 28.
Article em En | MEDLINE | ID: mdl-37506197
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Interferon Tipo I / COVID-19 Limite: Animals Idioma: En Revista: Sci Immunol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 4_TD Base de dados: MEDLINE Assunto principal: Interferon Tipo I / COVID-19 Limite: Animals Idioma: En Revista: Sci Immunol Ano de publicação: 2023 Tipo de documento: Article