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New Possible Ways to Use Exosomes in Diagnostics and Therapy via JAK/STAT Pathways.
Gombos, Gréta; Németh, Nikolett; Pös, Ondrej; Styk, Jakub; Buglyó, Gergely; Szemes, Tomas; Danihel, Ludovit; Nagy, Bálint; Balogh, István; Soltész, Beáta.
Afiliação
  • Gombos G; Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem Tér 1, H-4032 Debrecen, Hungary.
  • Németh N; Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem Tér 1, H-4032 Debrecen, Hungary.
  • Pös O; Comenius University Science Park, 841 04 Bratislava, Slovakia.
  • Styk J; Geneton Ltd., 841 04 Bratislava, Slovakia.
  • Buglyó G; Comenius University Science Park, 841 04 Bratislava, Slovakia.
  • Szemes T; Geneton Ltd., 841 04 Bratislava, Slovakia.
  • Danihel L; Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.
  • Nagy B; Department of Human Genetics, Faculty of Medicine, University of Debrecen, Egyetem Tér 1, H-4032 Debrecen, Hungary.
  • Balogh I; Comenius University Science Park, 841 04 Bratislava, Slovakia.
  • Soltész B; Geneton Ltd., 841 04 Bratislava, Slovakia.
Pharmaceutics ; 15(7)2023 Jul 07.
Article em En | MEDLINE | ID: mdl-37514090
ABSTRACT
Exosomes have the potential to be the future of personalized diagnostics and therapy. They are nano-sized particles between 30 and 100 nm flowing in the extracellular milieu, where they mediate cell-cell communication and participate in immune system regulation. Tumor-derived exosomes (TDEs) secreted from different types of cancer cells are the key regulators of the tumor microenvironment. With their immune suppressive cargo, TDEs prevent the antitumor immune response, leading to reduced effectiveness of cancer treatment by promoting a pro-tumorigenic microenvironment. Involved signaling pathways take part in the regulation of tumor proliferation, differentiation, apoptosis, and angiogenesis. Signal transducers and activators of transcription factors (STATs) and Janus kinase (JAK) signaling pathways are crucial in malignancies and autoimmune diseases alike, and their potential to be manipulated is currently the focus of interest. In this review, we aim to discuss exosomes, TDEs, and the JAK/STAT pathways, along with mediators like interleukins, tripartite motif proteins, and interferons.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Pharmaceutics Ano de publicação: 2023 Tipo de documento: Article