Extensive multiregional urea elevations in a case-control study of vascular dementia point toward a novel shared mechanism of disease amongst the age-related dementias.

Philbert, Sasha A; Xu, Jingshu; Scholefield, Melissa; Patassini, Stefano; Church, Stephanie J; Unwin, Richard D; Roncaroli, Federico; Cooper, Garth J S

Philbert, Sasha A; Xu, Jingshu; Scholefield, Melissa; Patassini, Stefano; Church, Stephanie J; Unwin, Richard D; Roncaroli, Federico; Cooper, Garth J S.

Afiliação

Philbert SA; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Xu J; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Scholefield M; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Patassini S; Faculty of Science, School of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Church SJ; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Unwin RD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Roncaroli F; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biology, Geoffrey Jefferson Brain Research Centre, The University of Manchester, Manchester, United Kingdom.
Cooper GJS; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, School of Medical Sciences, Centre for Advanced Discovery and Experimental Therapeutics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Front Mol Neurosci ; 16: 1215637, 2023.

Article em En | MEDLINE | ID: mdl-37520429

Palavras-chave

age-related neurodegeneration; dementia; mass spectrometry; metabolomics; urea; vascular dementia

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Tipo de estudo: Observational_studies Idioma: En Revista: Front Mol Neurosci Ano de publicação: 2023 Tipo de documento: Article

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