Modulating MGMT expression through interfering with cell signaling pathways.

Bai, Peiying; Fan, Tengjiao; Wang, Xin; Zhao, Lijiao; Zhong, Rugang; Sun, Guohui

Bai, Peiying; Fan, Tengjiao; Wang, Xin; Zhao, Lijiao; Zhong, Rugang; Sun, Guohui.

Afiliação

Bai P; Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Fan T; Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China; Department of Medical Technology, Beijing Pharmaceutical University of Staff and Workers, Beijing 100079, China.
Wang X; Department of Clinical Trials Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100029, China.
Zhao L; Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Zhong R; Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Sun G; Beijing Key Laboratory of Environmental and Viral Oncology, Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China. Electronic address: sunguohui@bjut.edu.cn.

Biochem Pharmacol ; 215: 115726, 2023 09.

Article em En | MEDLINE | ID: mdl-37524206

Assuntos

Neoplasias; O(6)-Metilguanina-DNA Metiltransferase; Humanos; O(6)-Metilguanina-DNA Metiltransferase/genética; O(6)-Metilguanina-DNA Metiltransferase/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Antineoplásicos Alquilantes/farmacologia; Neoplasias/metabolismo; Alquilantes/uso terapêutico; Transdução de Sinais; DNA; Metilases de Modificação do DNA/metabolismo; Metilases de Modificação do DNA/uso terapêutico; Proteínas Supressoras de Tumor/metabolismo; Enzimas Reparadoras do DNA/metabolismo; Enzimas Reparadoras do DNA/uso terapêutico

Palavras-chave

Alkylating agents; Cell signaling pathways; Cytotoxicity; Inhibitors; MGMT; Tumor resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: O(6)-Metilguanina-DNA Metiltransferase / Neoplasias Limite: Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2023 Tipo de documento: Article

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