Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance.

Nussinov, Ruth; Jang, Hyunbum

Nussinov, Ruth; Jang, Hyunbum.

Afiliação

Nussinov R; Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Cancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland, USA; email: NussinoR@mail.nih.gov.
Jang H; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Annu Rev Pharmacol Toxicol ; 64: 231-253, 2024 Jan 23.

Article em En | MEDLINE | ID: mdl-37524384

Assuntos

Antineoplásicos; Neoplasias; Humanos; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias/tratamento farmacológico; Paclitaxel; Alelos; Combinação de Medicamentos

Palavras-chave

AI; drug resistance; machine learning; signaling; targeted therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Annu Rev Pharmacol Toxicol Ano de publicação: 2024 Tipo de documento: Article

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